![]() ![]() Here, we define a molecular pathway linking expanded centromeres to histone phosphorylation and recruitment of microtubule destabilizing factors, leading to detachment of selfish centromeres from spindle microtubules that would direct them to the polar body. This centromere drive can explain the paradoxical rapid evolution of both centromere DNA and centromere-binding proteins despite conserved centromere function. ![]() Asymmetric division in female meiosis creates selective pressure favoring selfish centromeres that bias their transmission to the egg. ![]()
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